Aetiology and Genetics of Prostate Cancer

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This program is aimed at identifying the genes responsible for genetic predisposition to prostate cancer (thought to account for around 15% of cases) and is directed towards (i) identification and collection of prostate cancer families; (ii) identifying low and high penetrance genes which predispose to prostate cancer, and (iii) the development of a program of clinical management for individuals at high genetic risk of developing cancer. Other groups are focusing on understanding the role of diet in prostate cancer development (Professor David Phillips) and the setting up of selenium prevention trials (Dr Judith Bliss).