National Cancer Research Institute South of England
Prostate Cancer Collaborative
Research

Aetiology and Genetics of Prostate Cancer

Aetiology and Genetics of Prostate Cancer Diet and Environment Genetic Susceptibility
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This program is aimed at identifying the genes responsible for genetic predisposition to prostate cancer (thought to account for around 15% of cases) and is directed towards (i) identification and collection of prostate cancer families; (ii) identifying low and high penetrance genes which predispose to prostate cancer, and (iii) the development of a program of clinical management for individuals at high genetic risk of developing cancer. Other groups are focusing on understanding the role of diet in prostate cancer development (Professor David Phillips) and the setting up of selenium prevention trials (Dr Judith Bliss).

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Aetiology and Genetics

Epidemiological Identification of Families
Genetic Susceptibility
Diet and Environment
Chemoprevention

Molecular Pathology

Links to Cancer Genome Project
Development of Normal Prostate
Microarray Expression Profiling
Candidate Genes
Novel Telomerase Suppressor Genes
Subtractive Hybridization
CESH

Novel Therapies

New Drugs for Prostate Cancer
Intensity Modulated Radiotherapy
Immunotherapy
Novel Targets from Cancer Genome Project
Novel Mechanism Based Drugs

Core Resources

Cancer Gene Cloning Lab
Prostate Tissue arrays
Microarray laboratory
Tissue and blood collections
Bioinformatics

Pilot and Development Funds

Tumor micro-environment in early prostate cancer

Collaborations
Meetings and Seminars

Contact us on Email: cbell@icr.ac.uk Tel: 0208 643 8901 Fax: 0208 770 7290 This page last modified: 18/11/02